The Crucial Role of Th۲ Immunity in Late Pregnancy for Fetal Tolerance

This article explores the pivotal role of the Type ۲ T helper cell (Th۲) immune response in the maintenance of fetal tolerance during the later stages of pregnancy. As gestation progresses, a shift towards a Th۲-dominant immune environment, characterized by cytokines like IL-۴ and IL-۱۰, is observed. This immunological reprogramming is essential for accommodating the semi-allogeneic fetus and preventing detrimental inflammatory reactions that could lead to preterm birth or fetal loss. Furthermore, the Th۲ response influences placental function and trophoblast behavior, contributing to the prevention of pregnancy complications such as preeclampsia. This paper analyzes the molecular mechanisms underlying this phenomenon and its clinical significance in ensuring a full-term pregnancy.

کلیدواژه ها:

Th۲ response ، Pregnancy ، Fetal tolerance ، Immunotolerance ، IL-۴ ، IL-۱۰ ، Placenta ، Late birth ، Th۱/Th۲ balance ، Preeclampsia ، Preterm birth