Effect of PTZ-induced acute seizures on anxiety-like behaviors in open field test in male mice

Background: Seizures induce transient changes in behavior, including changes in anxiety-related exploration. In the present study the effect of acute pentylenetetrazol (PTZ)-induced seizures on activity and exploration in open-field test was investigated.Methods: Eight adult male C۵۷BL/۶ mice (weighing ۲۰-۲۵ g) were subjected to the open-field test before and ۲۴ hours after intraperitoneal administration of PTZ (۶۰ mg/kg) to induce an acute seizure model. Behavioral parameters, including time spent in the center zone (center time), number of crossings, and distance traveled in the center zone, were evaluated.Results: PTZ injection significantly reduced center time (P < ۰.۰۵) and had a large effect on reducing the number of crossings (d = ۱.۱۶) and center distance moved (d = ۰.۸) parameters. These data suggested a meaningful alterations in exploratory behavior following PTZ injection.Conclusion: These findings indicated that acute PTZ-induced seizures are associated with changes in anxiety-like behavior, particularly reflected by reduced exploration of the central area of the open-field arena.

کلیدواژه ها:

seizure ، Open field ، Exploration ، Pentylenetetrazol ، Anxiety