<span lang="EN-GB">The <span lang="EN-GB">impact <span lang="EN-GB">of Low- versus High-Dose Oxytocin Infusion on Maternal Hematologic and Hemodynamic Parameters after <span lang="EN-GB">Vaginal Delivery: A Randomized <span lang="EN-GB">Triple-<span lang="EN-GB">Blind Clinical <span lang="EN-GB">Trial

Background & aim: Postpartum hemorrhage is a major cause of maternal mortality. Although oxytocin is routinely used for prevention, optimal dose balancing uterine efficacy and maternal hemodynamic stability remains uncertain. This trial compared the impact of low-dose versus high-dose oxytocin infusion on maternal hematologic and hemodynamic parameters after vaginal delivery.Methods: This randomized, triple-blind clinical trial was conducted on ۶۰ primiparous women undergoing vaginal delivery at a teaching hospital affiliated with Neyshabur University of Medical Sciences, Neyshabour, Iran in ۲۰۲۴. Participants were randomly allocated ۱:۱ to low-dose (۱۰ IU) or high-dose (۶۰ IU) oxytocin infusion immediately after delivery. Hemoglobin and hematocrit were measured at admission and six hours postpartum. Blood pressure and heart rate were monitored for two hours postpartum. Data were analyzed using linear mixed-effects models.Results: Participants had a median age of ۲۱ years (interquartile range, ۱۹.۲۵–۲۵.۵۰ years), with similar baseline characteristics between groups. Maternal heart rate and body temperature showed no significant differences in two groups (P > ۰.۰۵). Although transient changes in systolic and diastolic blood pressure occurred at ۱۵ minutes postpartum, mixed-effects analysis showed no dose-dependent effects (P > ۰.۰۵). Hemoglobin and hematocrit decreased significantly from admission to six hours postpartum in both groups (p < ۰.۰۰۱), with no significant between-group differences.Conclusion: Low- and high-dose oxytocin infusion resulted in comparable maternal hemodynamic and hematologic outcomes during the early postpartum period. These findings support using the lowest effective dose to maintain uterine contraction while minimizing potential adverse effects.

کلیدواژه ها:

Oxytocin ، Hemoglobin ، Hematocrit ، blood pressure ، Heart rate ، Body Temperature Postpartum Hemorrhage