Nanoparticles in The Diagnosis and Treatment of Alzheimer’s: Disease Focus on Gold Nanoparticles

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-beta (Aβ) plaques and neurofibrillary tangles in the brain, leading to cognitive impairment and memory loss. Nanotechnology has emerged as a promising approach for overcoming the limitations of traditional diagnosis and treatment methods for AD. This review explores the potential of various nanoparticles (NPs) in AD diagnosis and therapy. Functionalized NPs can cross the blood-brain barrier (BBB) and target specific pathological markers, enabling early detection and quantification of Aβ oligomers, plaques, and tau aggregates. The unique optical, electrical, and surface properties of NPs have facilitated the development of sensitive biosensors for detecting AD biomarkers. This review highlights the diverse applications of NPs in AD, including their diagnostic capabilities, therapeutic effects, and mechanisms of transport across the BBB. Additionally, it discusses the future prospects of NP-based strategies for AD management, emphasizing the need for improved formulations and targeted approaches.

کلیدواژه ها:

Alzheimer's disease ، Nanoparticles for Alzheimer's therapy ، neurodegenerative disorder