A Critical Investigation of Metal–Polyphenol Nanoparticles [M(n⁺) (Polyphenol)_m​] and Their Role in Regulating Inflammatory Responses in Biological Systems

In recent years, metal–polyphenol nanomaterials have attracted attention as a new generation of biocompatible materials due to their unique chemical and biological properties. Polyphenols, which are natural compounds with antioxidant and anti-inflammatory properties, bind to metal ions and form stable networks with tunable physical and chemical properties. Quantitative data extraction focused on synthesis parameters (pH, molar ratio, reaction time), physicochemical characterization (size, zeta potential, polydispersity index), and anti‑inflammatory outcomes (ROS reduction, cytokine inhibition, wound closure rate). These nanostructures can effectively control the inflammatory process by inhibiting oxidative reactions and reducing inflammatory cytokine production. In addition, metal–polyphenol nanomaterials have found wide application in several fields such as targeted drug delivery, tissue repair, and the design of antibacterial and anti-inflammatory coatings due to their high biocompatibility and multifunctionality. This statistical synthesis demonstrates that MPN anti‑inflammatory efficacy is highly tunable through metal/polyphenol selection, but standardized reporting and long‑term toxicity studies remain critical gaps for clinical translation. This paper reviews recent studies on the structure, properties, and anti-inflammatory applications of these nanomaterials and examines their place in future biomedical research.

کلیدواژه ها:

Metal&ndash ، polyphenol nanomaterials ، Biocompatibility ، Antioxidant properties ، Inflammatory cytokines ، Targeted drug delivery