A Comparison of Seizure Prophylaxis in Brain Traumatic Injury: Sodium Valproate Versus Levetiracetam

Introduction: Literature is rife with discordant results regarding the use of antiepileptic drugs for prophylaxis of Post-traumatic epilepsy. This study was conducted in Isfahan hospitals to compare the effectiveness of Sodium Valproate and Levetiracetam in preventing early seizures in patients with traumatic brain injuries.Method: A total of ۱۶۰ patients with traumatic brain injury treated in Kashani Hospital (Isfahan, Iran) from ۲۰۲۴ to ۲۰۲۵ were enrolled and divided into group A (n=۸۰) and group B (n=۸۰) according to random sampling. The medication was continued for ۳ months after the injury.Result: There were no statistically significant differences in demographic and clinical information between the two groups (P>۰.۰۵). We failed to determine a significant relationship between the antiepileptic drug used and the initial EEG (P=۰.۵۸۴) and seizure activity (P= ۰.۶۸۰) between the two drug groups. However, a significant correlation between the antiepileptic drug used and seizure activity was found at subsequent follow-ups (۱۰, ۱۸۰ days); patients who took levetiracetam had a decreased incidence of seizure activity at follow-ups. There was no significant correlation between the GCS score, both initially and on two follow-ups, and the antiepileptic drug used.Conclusion: Logically, it would seem that the long-lasting high risk of epilepsy after brain injury might be reduced if prophylactic antiepileptic drugs are administered. Looked specifically at prophylactic antiepileptic drugs post-TBI and reported a better safety profile, with a lower adverse drug reaction rate, for Levetiracetam versus Sodium Valproate.

کلیدواژه ها:

Seizure ، Prophylaxis ، Brain Traumatic Injury ، Sodium Valproate ، Levetiracetam