The Impact of Food Vitamins and Minerals on Proliferation, Differentiation, Homeostasis and Regenerative Capacity of Body Mesenchymal Stem Cells: A Narrative Review

Several lines of evidence confirmed the idea that stem cells are among the major players in orchestrating the response of our body to nutrients, mainly due to their crucial role in tissue homeostasis as dietary components and nutritional status can significantly impact stem cell survival and performance in human body and subsequently health status. This review concentrated on literature findings to determine the impact of food components on function, proliferation, differentiation, homeostasis, and regenerative capacity of body mesenchymal stem cells by searching related databases and focusing on related keywords from June ۲۰۰۰ to June ۲۰۲۶. Even many studies regarding the impact of vitamins and mineral components on proliferation, differentiation, homeostasis and regenerative capacity of body mesenchymal stem cells are in vitro and require in vivo validation; but the positive physiological effects of vitamins and minerals through several mechanisms in the literature reflect their pivotal role in regenerative medcicne. It seems that improving nutritional intake and biochemical status of key micronutrients (e.g. vitamins and minerals) can be supportive for the efficacy of MSCs in therapies and immune function and subsequently the recovery and clinical outcome of patients. A proper food intake can particularly target the enhancement of stem cell activity, epigenetic regulation, redox–inflammatory pathways and cellular metabolism. In this review, mitochondrial metabolic checkpoint regulating stem cell maintenance was highlighted. It was discussed how diet affects the metabolism of stem cells through the nutrient sensing pathways, thereby affecting stem cell fate decision and tissue regeneration.

کلیدواژه ها:

Food ، Diet ، vitamins ، Minerals ، Mesenchymal Stem Cells