Evaluation of Inflammatory Cytokines and Vitamin D۳ Serum Levels in Patients with Tuberculosis in Baghdad, Iraq

Background: Tuberculosis (TB) due to Mycobacterium tuberculosis infection is a public health issue frequently connected with cytokine storm. Vitamin D۳ deficiency was shown to increase the susceptibility to TB. This study assessed the serum levels of inflammatory cytokines and vitamin D۳ in Iraqi patients infected to TB.Methods: A total of ۳ mL of blood was collected from ۷۲ TB patients and ۷۲ healthy controls to evaluate the interleukin-۲ (IL-۲), IL-۱۰, and IL-۱۷ levels by Enzyme-Linked Immunosorbent Assay (ELISA), and the vitamin D۳ level using auto-analyzer.Results: A significant increase in IL-۲ (p<۰.۰۰۰۱), IL-۱۰ (p<۰.۰۰۰۱), and IL-۱۷ (p<۰.۰۵) in TB patients was noticed compared to control group. A significant decrease in vitamin D۳ was observed in TB patients compared to control group (p<۰.۰۲). Among TB patients a significant increase was seen in IL-۲ (p<۰.۰۰۲), IL-۱۰ (p<۰.۰۵), and non-significant increase in IL-۱۷ (p<۰.۱۳). A significant decrease in vitamin D۳ (p<۰.۰۵) was demonstrated among drug resist patients compared to drug sensitive patients within TB group.Conclusion: IL-۲, IL-۱۰, and IL-۱۷ serum levels were illustrated to be useful immunodiagnostic markers between TB-infected patients and TB-uninfected individuals. Vitamin D۳ was demonstrated to have supportive role in TB patients.

کلیدواژه ها:

Tuberculosis ، IL-۲ ، IL-۱۰ ، IL-۱۷ ، Vitamin D۳