Evaluation of the effects of Asparagus racemosus extract (ARova۵X) supplementation on postmenopausal discomfort

Objective: Menopause is a critical physiological transition often associated with a spectrum of health challenges such as sexual dysfunction, vasomotor symptoms, and increased oxidative stress. This study aimed to evaluate the efficacy of a hydroalcoholic extract of Asparagus racemosus root (ARova۵X), standardized to contain ۵% shatavarins, in improving health outcomes among postmenopausal women.Materials and Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted at Apollo Hospitals, Hyderabad, India, during January ۲۰۲۴-۲۰۲۵. A total of ۲۱۴ postmenopausal women were randomly assigned to receive either ARova۵X (۲۵۰ mg/day) or placebo for ۹۰ days (n=۱۰۷ per group). Outcome measures were assessed at baseline and post-intervention using validated tools including the Sexual Quotient-Female (SQ-F) questionnaire, the Female Intervention Efficacy Index (FIEI), oxidative stress markers, and anthropometric parameters. Primary endpoints included changes in sexual function, menopausal symptoms, oxidative stress, and weight-related measures.Results: Participants receiving ARova۵X showed significant improvements in multiple domains of sexual function including desire (p<۰.۰۰۱), foreplay (p=۰.۰۰۲), arousal (p<۰.۰۰۱), and satisfaction (p=۰.۰۰۴) compared to the placebo group. Vaginal lubrication improved by ۸۴.۱۱% in the intervention group compared to ۱۳.۰۸% in the placebo group. Oxidative stress levels were markedly reduced, with ۳۹.۲۵% of women in the ARova۵X group reaching minimal stress levels. Clinical obesity prevalence decreased from ۴۲.۹۹% to ۲۹.۹۱%. Menopausal symptoms such as hot flashes, fatigue, and irritability were also significantly alleviated.Conclusion: ARova۵X appears to be a safe, effective natural intervention for improving sexual health, reducing oxidative stress, and supporting weight management in postmenopausal women.

کلیدواژه ها:

Menopause ، Asparagus racemosus ، Sexual dysfunction ، Oxidative stress ، Phytotherapy