Clinical, Histopathological Features and Management Outcomes of Ovarian Tumors in Pediatric Girls: A Retrospective Single-Center Study at Da Nang Hospital for Women and Children, Vietnam (۲۰۲۴)

Background & Objective: To describe clinical presentation, ultrasound characteristics, histopathology, and management outcomes of ovarian tumors in pediatric girls at Da Nang Hospital for Women and Children, Vietnam, and to examine associations between selected clinical or ultrasound factors and adnexal torsion or malignant histology. Materials & Methods: A retrospective chart review was conducted for girls aged≤۱۵ years who underwent surgery for ovarian tumors at Da Nang Hospital for Women and Children between January and December ۲۰۲۴. Variables included presenting symptoms, ultrasound morphology, tumor size, tumor markers (Cancer Antigen ۱۲۵ (CA-۱۲۵), Lactate Dehydrogenase (LDH), and Alpha-Fetoprotein (AFP), when available), operative approach, surgical procedures, histopathology, and intraoperative adnexal torsion. Associations were evaluated using Chi-square or Fisher’s exact tests and the Mann-Whitney U test, as appropriate. Results: Twenty-nine girls (age ۴-۱۵ years; mean ۱۱.۶±۲.۹ years) underwent surgery. Abdominal pain was present in ۹۶.۶%, abdominal distension in ۲۴.۱%, and nausea/vomiting in ۱۰.۳%. All tumors were unilateral; ۶۹.۰% measured<۱۰ cm on ultrasound. A solid component was identified in ۲۰.۷% of cases and was associated with malignant histology in exploratory analysis (P=۰.۰۳۶). Mature teratoma accounted for ۵۸.۶% of tumors, while immature teratoma accounted for ۶.۹%. Laparoscopy was performed in ۹۳.۱% of cases, with ovarian-sparing tumor excision achieved in ۸۶.۲%. Nausea/vomiting was associated with adnexal torsion in exploratory analysis (P=۰.۰۲). Conclusion: Most pediatric ovarian tumors requiring surgery were benign and were successfully managed laparoscopically with high rates of ovarian preservation. The presence of a solid component on ultrasound may raise suspicion for malignant histology; however, this finding should be interpreted cautiously due to the small sample size.

کلیدواژه ها:

adnexal torsion ، CA-۱۲۵ ، laparoscopy ، pediatric ovarian tumor ، Ultrasound ، Teratoma