Association of Estrogen Receptor Expression with Early Postoperative Inflammation Within the First ۲۴ Hours After Lumpectomy

Introduction: Early postoperative inflammation after lumpectomy may be influenced by tumor biology, particularly estrogen receptor expression, which modulates immune signaling and cytokine activity. However, its relationship with surgical inflammation remains unclear. This study aimed to evaluate the association between estrogen receptor expression and inflammatory responses during the first ۲۴-hour postoperative period.Material and methods: This descriptive cross-sectional study was conducted at Tabriz University of Medical Sciences in ۲۰۲۶ on ۴۵ women undergoing lumpectomy, selected by convenience sampling. Estrogen receptor expression was assessed immunohistochemically in surgical specimens, while early postoperative inflammation was evaluated by ۲۴-hour serum C-reactive protein measurement. Additional variables included age, body mass index, menopausal status, tumor characteristics, operative duration, white blood cell count, temperature, drainage volume, and pain score.Results: Our study demonstrated that ER-negative patients exhibited a more pronounced inflammatory response post-lumpectomy. The ER-negative group showed significantly higher ۲۴-hour CRP (۱۶.۸۳ vs. ۱۲.۴۶ mg/L; p=۰.۰۰۱) and WBC counts (۱۰.۰۸ vs. ۸.۷۱ × ۱۰³/µL; p=۰.۰۱۷) than ER-positive patients. Regression analysis confirmed an independent inverse association between ER expression and postoperative CRP levels (adjusted β=۳.۹۲; p=۰.۰۰۳), underscoring a distinct link between molecular phenotype and acute systemic inflammatory intensity.Conclusion: ER-negative status in breast cancer patients significantly exacerbates the systemic inflammatory response during the first ۲۴ hours after lumpectomy. This association suggests that ER expression serves as a critical molecular biomarker for early postoperative recovery. Consequently, patients with ER-negative tumors may require heightened clinical surveillance and targeted anti-inflammatory interventions to manage the observed surge in acute inflammatory markers following surgical resection.

کلیدواژه ها:

Estrogen Receptor ، Lumpectomy ، postoperative inflammation ، C-reactive protein