Association Between Progesterone Receptor Expression and the Incidence of Acute Postoperative Complications Following Lumpectomy

Introduction: Lumpectomy is a standard breast-conserving procedure, yet acute postoperative complications may delay recovery and adjuvant treatment. Beyond clinical risk factors, tumor biology may influence wound healing and inflammatory responses. This study aimed to evaluate the association between progesterone receptor expression and the incidence of acute postoperative complications following lumpectomy.Material and methods: This descriptive cross-sectional study was conducted at Tabriz University of Medical Sciences in ۲۰۲۵ on ۵۴ women undergoing lumpectomy, with sample size estimated using the Cochran formula and participants enrolled by convenience sampling. Progesterone receptor expression was assessed by immunohistochemistry on surgical specimens, and its association with acute postoperative complications was analyzed alongside demographic, clinical, pathological, and perioperative variables using appropriate statistical tests.Results: Results summary: Among ۵۴ patients undergoing lumpectomy, PR-negative status was associated with poorer early postoperative outcomes. Compared with PR-positive patients, PR-negative patients had higher postoperative VAS scores (۴.۰۶ ± ۱.۴۳ vs. ۳.۱۴ ± ۱.۲۱; p = ۰.۰۱۷), more acute complications (۵۰.۰۰% vs. ۲۲.۲۲%; p = ۰.۰۳۷), and more unplanned visits (۳۳.۳۳% vs. ۱۱.۱۱%; p = ۰.۰۴۸). PR negativity independently predicted complications after adjustment (OR = ۳.۸۴; p = ۰.۰۳۹).Conclusion: PR-negative status was associated with a higher risk of acute postoperative complications after lumpectomy. Despite broadly comparable operative variables, PR-negative patients experienced greater postoperative morbidity and more unplanned visits, suggesting that receptor status may help identify patients requiring closer early postoperative monitoring.

کلیدواژه ها:

Progesterone Receptor ، Lumpectomy ، Postoperative complications ، breast cancer