Direct O-monofluoromethylation of phenol derivatives: An efficient and straightforward route to monofluoromethoxy arenes

Monofluoromethoxy arenes have attracted considerable research interest in the fields of agrochemicals, pharmaceuticals and functional materials, forging the development of new synthetic methods to access this class of fluorine-containing organic molecules. Direct monofluoromethylation of easily accessible phenol derivatives has recently emerged as a promising approach for synthesizing the titled compounds. The aim of the present work is to summarize the recent advances on the topic, covering the period between January ۲۰۰۰ and October ۲۰۲۴. The review is divided in five main parts, according to the type of monofluoromethylation reagents.

کلیدواژه ها:

organofluorine compounds ، monofluoromethylation ، monofluoromethoxy arenes ، Phenols ، halofluoromethanes