Recent advances in the regioselective C-۲ and C-۳ double C-H sulfenylation of indoles

Organic sulfides are widely used in the pharmaceutical, agrochemical, and material fields. Thus, these classes of organosulfur compounds are of immense interest in the fields of organic synthesis and medicinal chemistry. Among various organic sulfides, ۲,۳-disulfenyl indoles have drawn increasing attention due to their unique biological activities. In recent years, several methods for the synthesis of titled compounds through the direct double C-H sulfenylation of indoles have been rapidly developed. In this review, we summarize the results of recent exciting reports regarding double sulfenylation reactions of indoles with various sulfenylating reagents.

کلیدواژه ها:

vicinal difunctionalization ، C-H bond functionalization ، sulfenylation ، C-S bond formation