Astrocytic Na+/K+ Pump in Seizure Suppression: Mathematical Modeling and Calcium-Independent Anti-Seizure Effect

Epilepsy is marked by recurrent seizures from abnormal brain activity. This study investigates the astrocytic sodium-potassium pump's role in regulating ionic balance and suppressing seizures using a neuron-astrocyte mathematical model. Optogenetic stimulation was simulated to activate astrocytes and enhance pump activity. Increasing pump activity reduced seizure severity and neuronal firing. This calcium-independent anti-seizure effect is linked to potassium removal and ionic regulation. The astrocytic pump is proposed as a central seizure-suppression mechanism and a novel therapeutic target.

کلیدواژه ها:

epilepsy ، sodium-potassium pump ، astrocyte ، mathematical modeling ، optogenetic