Impact of Clot Length on Thrombolytic Treatment using Different Types of Tissue-type Plasminogen Activators

The therapeutic approach of intravenous thrombolysis for acute ischemic stroke entails the administration of tissue plasminogen activator (tPA) to lyse the occlusive thrombus and restore cerebral perfusion. In this study, we investigate how clot length influences the timing of vessel recanalization, using a developed computational modeling framework for thrombolysis. A two-dimensional arterial geometry was constructed representing the bifurcation of the internal carotid artery into the middle cerebral artery and the anterior cerebral artery. Six simulation scenarios were performed by varying both clot length and the thrombolytic agent used. The results indicate that alteplase and tenecteplase have similar lysis activation and vessel recanalization times. Furthermore, the time required for complete clot dissolution increases in an approximately quadratic manner with respect to the initial clot length.

کلیدواژه ها:

Thrombolysis ، Clot length ، Alteplase ، Tenecteplase ، Mathematical modeling