Novel formulations targeting pyroptosis in cancer and inflammatory diseases

Pyroptosis is a type of programmed cell death that has been linked to various inflammatory diseases and cancer progression. Inflammatory responses initiated by pyroptosis can either block or promote cancer depending on the tumor microenvironment (TME) and immune evasion. Progresses in nanobiotechnology could allow for the precise delivery of drugs or gene therapy agents that modulate pyroptosis pathways. This could ensure that therapeutic interventions are targeted directly to the inflamed or tumor regions, minimizing systemic side effects. The field of pyroptosis-based formulations for treating cancer and inflammatory diseases is still evolving. Therefore, further research is needed to address the challenges of specificity, resistance, and safe clinical implementation. Novel formulations and strategies, such as DNA demethylation targeting pyroptosis in cancer and inflammatory diseases, are a promising and rapidly evolving field of research. This review has tried to present and explain recent formulations targeting pyroptosis in cancer and inflammatory diseases.

کلیدواژه ها:

inflammatory responses ، Tumor Microenvironment ، Immune Evasion ، Inflamed regions ، DNA demethylation