Design, Synthesis, and Biological Evaluation of Bis-Imine-Based Metal Complexes

The new bis-imine ligand was synthesized by the condensation reaction of ۱-((۳-(۴-fluorophenyl)-۱-isopropyl-۱H-indol-۲-yl)methylene) hydrazine with ortho-vanillin. The synthesized ligand was subsequently employed to produce diverse transition metal complexes through the combination with suitable metal salt solutions on subsequent heating. Using UV-Vis, FTIR, ۱H-NMR spectroscopy, and mass spectrometry, the functional groups, coordination interaction, and probable morphologies of the synthesized compounds were examined. On spectral data basis, it was confirmed that the ligand and its metal complexes were made. The ligand and its metal complexes were evaluated to determine their potential biological consequences. The biological activity results showed that specific metal complexes were more effective than the free ligand. Certain combinations exhibited promising effectiveness against antibacterial, anti-tuberculosis, and antimalarial activities. The results indicate that coordination of the bis-imine ligand with metal ions improves its suitability for biological activity. The indole-based bis-imine metal complexes could be ideal candidates for developing new biologically active molecules for medical applications.

کلیدواژه ها:

Bis-imine Ligand ، Metal complexes ، Antituberculosis ، Antimicrobial and Antimalarial activities