Prognostic Value and Predictive Utility of CA۱۵ ۳ and CRP as Pathophysiological Biomarkers in Patients with Breast Cancer Undergoing Chemotherapy

Introduction: Breast cancer outcomes vary widely, creating a need for accessible biomarkers that reflect tumor burden and systemic inflammation during chemotherapy. CA۱۵ ۳ and CRP may provide complementary prognostic and predictive information. This study aims to evaluate the prognostic value and predictive utility of CA۱۵ ۳ and CRP in patients with breast cancer undergoing chemotherapy.Material and methods: This descriptive cross-sectional study will be conducted at Shahid Madani Hospital, Tabriz University of Medical Sciences, using convenience sampling to enroll ۷۰ breast cancer patients undergoing chemotherapy. Demographic, clinicopathological, and treatment data, along with serum CA۱۵-۳ and CRP levels, will be collected and analyzed using appropriate descriptive and inferential statistics.Results: In ۷۰ patients with breast cancer undergoing chemotherapy, the mean age was ۴۹.۸ ± ۱۰.۷ years; ۸۰.۰% had invasive ductal carcinoma, ۷۰.۰% had lymph node involvement, and ۱۸.۶% had metastasis. Median CA۱۵-۳ and CRP levels were ۳۱.۵ U/mL and ۸.۹ mg/L, respectively.Conclusion: These findings indicate that CA۱۵-۳ and CRP reflect related but non-identical biological dimensions in patients with breast cancer undergoing chemotherapy. While CA۱۵-۳ appears to represent tumor-associated activity, CRP likely captures the accompanying systemic inflammatory response.

کلیدواژه ها:

breast cancer ، CA۱۵-۳ ، C-reactive protein ، Chemotherapy ، Biomarkers