Analysis of Insulin Resistance Markers and Lipid Profile in Patients in Baghdad, Iraq

Background: Insulin resistance (IR) is a detrimental common condition related to type ۲ diabetes mellitus and different metabolic diseases. The common indices are the homeostasis model assessment of insulin resistance (HOMA-IR) and triglyceride glucose (TyG) index. This study analyzed IR markers and lipid profile in patients in Baghdad, Iraq.Methods: A cross-sectional study from March ۷ ۲۰۲۴ to June ۱st ۲۰۲۴ was performed at Nutrition and Obesity Center in Al-Kindy Hospital, Baghdad, Iraq enrolling ۱۰۰ participants (۸۱ females and ۱۹ males) aged between ۱۸-۶۰ years. They were categorized into obese and non-obese groups based on their BMI values. BMI, fasting blood glucose, fasting insulin and lipid profile (total cholesterol, triglycerides, LDL-C, and HDL-C) and HbA۱C were determined and analyzed.Results: HOMA-IR index detected ۳۸% of IR individuals, while TyG index verified ۵۱%. BMI was shown to be correlated too (p=۰.۰۰۰۱, p=۰.۰۳۳, respectively). For lipid profile, LDL-C and total cholesterol were inversely related to HOMA-IR index (p=۰.۰۴۸, p=۰.۱۶۳, respectively). HDL-C had inverse relationship with HOMA-IR (p=۰.۰۱۴), and triglyceride had a positive correlation with HOMA-IR (p=۰.۱۹۰). TyG revealed a positive correlation with total cholesterol and triglyceride (p=۰.۰۰۰۶, p=۰.۰۰۰۱, respectively). The correlation between TyG index and LDL was positive, and forTyG and HDL was negative (p=۰.۱۰۵, p=۰.۱۷۹, respectively).Conclusion: TyG index was superior to HOMA-IR with a stronger positive correlation to the BMI marker too. Lipid profile revealed a weak relationship with HOMA-IR ant TyG indices.

کلیدواژه ها:

Insulin Resistance ، Triglyceride glucose index ، HOMA-IR index ، BMI ، Lipid profile