The Relationship between MCR۴ and Lipid Profile in Metabolic Syndrome

Background: Metabolic syndrome (MetS) is a multifactorial disorder marked by obesity, dyslipidemia, hypertension, and insulin resistance, which increase the risk of cardiovascular diseases and type ۲ diabetes mellitus. Genetic factors, including polymorphisms in the Melanocortin-۴ receptor (MC۴R) have been linked to its development, especially regarding lipid metabolism and obesity. This study aimed to investigate the association between the MC۴R (rs۱۷۷۸۲۳۱۳) C/T polymorphism and lipid profile in individuals with MetS compared to healthy controls.Methods: A case-control study was conducted with ۱۵۰ Iraqi participants including ۷۵ MetS patients and ۷۵ healthy controls. Anthropometric measurements and lipid profile were recorded. Genotypic distribution of the MC۴R (rs۱۷۷۸۲۳۱۳) polymorphism was analyzed using ARMSPCR. Statistical analyses assessed the correlation between MC۴Rpolymorphisms, lipid profile, and risk of MetS.Results: Patients with MetS showed significantly higher BMI, waist circumference, triglycerides, total cholesterol, and low density lipoprotein (LDL) levels when compared to controls. The TT genotype of MC۴R (rs۱۷۷۸۲۳۱۳) was more prevalent among patients (۲۴%) than controls (۱۲%), associated with increased risk of MetS (OR=۲.۸۱, p=۰.۰۲۴). The T allele was also more common in patients (۴۰.۷%) than in controls (۲۶%) (p=۰.۰۰۷, OR=۱.۹۵).Conclusion: Findings suggest a strong association between MC۴R (rs۱۷۷۸۲۳۱۳) polymorphism, lipid abnormalities, and MetS. The T allele and TT genotype may serve as genetic markers for increased susceptibility. Further studies are needed to clarify the molecular mechanisms behind therapeutic interventions targeting this receptor

کلیدواژه ها:

Metabolic Syndrome ، MC۴R ، Lipid profile ، Iraq