Anti-Inflammatory Effect of Acetylcysteine and Royal Jelly against Fluoxetine-Induced Hepatotoxicity in Rats

Background: Hepatic toxicity of antipsychotic drugs needs to be protected by hepatoprotective medications. This study evaluated the antiinflammatory effect of N-acetylcysteine (NAC) and Royal jelly against hepatotoxicity of fluoxetine in rats.Methods: Thirty adult female rats were divided into five equal groups of ۶ rats. Group A was considered negative control. Group B were rats administered orally by fluoxetine (۱۰ mg\kg) to induce hepatotoxicity. Group C were animals pre-treated with oral NAC (۲۰۰ mg\kg) and then fluoxetine (۱۰ mg\kg). Group D was pre-treated with Royal jelly (۱۵۰ mg\kg) following the use of fluoxetine (۱۰ mg\kg). Group E was pretreated with oral Royal jelly and NAC following fluoxetine utilization. After completion of ۲۸ days of treatment, the rats were euthanized and a blood sample was collected and evaluated for inflammatory cytokines of tumor necrotizing factor alpha (TNF-α), interleukin-۱۰ (IL۱۰) and oxidative stress biomarkers of malondialdehyde (MDA) and glutathione (GSH) by ELISA.Results: Fluoxetine induced hepatotoxicity and an increase in inflammatory cytokines such as TNF-α. Royal jelly and NAC showed significant anti-inflammatory and antioxidant effects by reduction in inflammatory cytokines and oxidative parameters.Conclusion: Both NAC and Royall jelly were shown to have antioxidant and anti-inflammatory activities, even NAC impact was more than Royal jelly against hepato toxicity induced by fluoxetine.

کلیدواژه ها:

Acetylcysteine ، Fluoxetine ، Hepatotoxicity ، Inflammation ، Royal jelly