The Effects Of Curcumin On Olfactory Dysfunction and Indoxyl Sulphate In Hemodialysis Patients

Introduction: Neurological abnormalities in uremic conditions are indicated by olfactory impairment in the population with long-term renal disease, which escalates in prevalence with the degree of severity of renal disease. Indoxyl Sulphate is a kind of toxic substance that exacerbates kidney damage. Since it scavenges ROS or reactive oxygen species, curcumin helps prevent disease development and promotes olfactory ensheathing cell growth and viability under normal and hypoxic settings. Method: For ۱۲ weeks, ۴۸ patients with stage ۵ chronic renal disease receiving regular haemodialysis were split into three groups: the control group, the ۵۰۰ mg curcumin group, and the ۱۰۰۰ mg curcumin group. Plasma indoxyl Sulphate concentrations and subsequent olfactory function were assessed. The results were compared using bivariate and multivariate analysis. Results: The olfactory function delta (p=۰.۰۰۲) and discrimination of olfactory delta (p=۰.۰۰۱) of the ۵۰۰ mg and ۱۰۰۰ mg curcumin groups differed significantly. The ۵۰۰ mg curcumin group's IS levels (p=۰.۰۰۸) and the control group's (p=۰.۰۱۹) delta IS level (p=۰.۸۷۰) were significantly different from the ۱۰۰۰ mg curcumin olfactory group's olfactory identification (p=۰.۰۰۶) and delta identification (p=۰.۶۱۸). The olfactory thresholds of the three study groups did not differ significantly (p=۰.۶۳۶). Conclusion: Curcumin therapy alleviated olfactory impairment in individuals with chronic renal illness; no increase in indoxyl Sulphate levels was observed, suggesting that curcumin may stabilize the toxin.

کلیدواژه ها:

Curcumin ، indoxyl sulphate ، Olfactory dysfunction ، chronic kidney disease