Necroptosis in cancer: A mini-review about novel formulations

Necroptosis is an inflammatory form of programmed cell death distinct from apoptosis and feroptosis. In contrast to apoptosis, which involves caspase activation, necroptosis is regulated by receptor-interacting protein kinase ۱ (RIPK۱) and RIPK۳, leading to the formation of the necrosome. This complex promotes cell rupture and inflammation. As a therapeutic strategy, promoting the mixed lineage kinase domain-like protein (MLKL) can increase necroptosis in cancerous tissues through phosphorylation, membrane insertion, and the formation of membrane hotspots. In cancer, necroptosis has gained significant attention as a potential therapeutic avenue, particularly as an alternative to traditional treatments similar to chemotherapy and radiotherapy. This mini-review aims to explore recent advancements in necroptosis research, focusing on novel micro- and nanoformulations that aim to regulate this pathway for cancer therapy.

کلیدواژه ها:

Caspase activation ، Necrosome ، Membrane insertion ، Nanoformulations