Stem cell formulations based on natural polymers for tissue engineering: A literature review

Stem cell therapy represents a promising strategy for regenerative medicine; however, its clinical translation is limited by poor cell survival, low engraftment efficiency, and uncontrolled differentiation. Biomaterials, particularly those based on natural polymers, have emerged as effective platforms for enhancing stem cell delivery and therapeutic performance. Natural polymers, such as collagen, gelatin, alginate, chitosan, hyaluronic acid, cellulose, and silk fibroin, closely mimic the extracellular matrix, presenting superior biocompatibility, biodegradability, and bioactivity. This review summarizes recent advances in natural polymer-based hydrogels and scaffolds for stem cell therapy, highlighting their physicochemical properties, biological interactions with stem cells, and applications in tissue regeneration. Moreover, current challenges and future perspectives toward clinical translation have been discussed.

کلیدواژه ها:

Stem cell therapy ، Natural Polymers ، hydrogels ، Scaffolds ، Tissue engineering ، Regenerative medicine