Chronotherapeutic Effects of Atorvastatin Administration on Lipid Profile in Patients with Type ۲ Diabetes Mellitus: A Randomized Clinical Trial

Background: Type ۲ diabetes mellitus (T۲DM) is commonly associated with dyslipidemia and increased cardiovascular risk. Atorvastatin, a widely used statin, effectively improves lipid profiles. This study aimed to compare the effects of morning versus evening administration of atorvastatin on lipid parameters in patients with T۲DM.Materials and Methods: This randomized controlled trial enrolled ۷۶ patients with T۲DM, randomly assigned to receive Atorvastatin ۴۰ mg either in the morning (n=۳۸) or evening (n=۳۸) for ۴ weeks. Fasting serum triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured at baseline and post-treatment. Baseline lipid values were included as covariates in ANCOVA to compare post-treatment levels between groups.Results: Atorvastatin significantly improved lipid profiles in both groups: LDL-C, TG, and TC decreased (P<۰.۰۵), while HDL-C increased (P<۰.۰۰۱) compared to baseline. After adjusting for baseline values, no significant differences were observed between morning and evening groups in LDL-C, HDL-C, TG, or TC (P>۰.۰۵).Conclusion: Four weeks of Atorvastatin therapy significantly improved lipid profiles in patients with T۲DM, irrespective of administration time. These findings suggest that dosing flexibility may enhance patient adherence without compromising efficacy.

کلیدواژه ها:

Type ۲ diabetes mellitus ، Atorvastatin ، Lipid profile ، Statin ، Morning vs evening administration ، Randomized clinical trial