Efficient synthesis of ۱,۲,۳-triazoles catalyzed by copper(I) Schiff base complex

Herein, a tricoordinate Cu(I) complex was synthesized employing a neutral bidentate Schiff base (L۴Cl), via the condensation of ۴-chlorobenzaldehyde with ۲,۲-dimethylpropane-۱,۳-diamine, followed by complexation with copper(I) iodide. The structural features of the ligand and its corresponding complex were confirmed by FT-IR, ۱H and ۱۳C{۱H} NMR spectroscopy, along with elemental (CHN) analysis. Moreover, the catalytic efficiency of the complex was evaluated in the one-pot synthesis of ۱,۲,۳-triazoles, which are effective anticancer agents, via a three-component reaction involving phenylacetylene, sodium azide, and various benzyl bromides in aqueous medium. The optimized reaction conditions offer significant advantages, including shorter reaction times, high yields, reduced reaction temperature, and a simplified product isolation process. The efficient synthesis of triazoles using the Cu(I) complex highlights its potential as a promising catalyst for future advancements in drug development targeting malignant cells.

کلیدواژه ها:

۱ ، ۲ ، ۳-triazole ، Aqueous medium ، Copper(I) complex ، Bidentate Schiff base ، Homogeneous catalysis