Invitro applications of some novel Metallo-Mannich bases based on acyclovir: Antimicrobial and antioxidant activity

This study investigates the novel synthesis of Mannich base complexes, including V(IV), Ru(III), Pt(IV), and Au(III), which are produced from the Acyclovir-Mannich base. All structures of these novel compounds were described using spectroscopic approaches, including ۱H,۱۳C-NMR, UV-Vis, mass spectrometry, FTIR, metal, and elemental analysis, in addition to magnetic susceptibility and conductivity measurements. The diagnosis found that the VO-complex possesses a square pyramidal geometry, the Au-complex exhibits square planar geometry, and the Ru and Pt complexes are octahedral. All synthesized compounds were subjected to the antioxidant assay. The antioxidant activity indicates that the Ru (III) complex exhibited superior antioxidant efficacy compared to the others. The value of IC۵۰ concerning this combination was ۳۱۱.۵۰ μg/ml. The study also involves evaluating the efficacy of these compounds in inhibiting the bacteria Acinetobacter baumannii, a Gram-negative, and Streptococcus pyogenes, a Gram-positive, as well as their antifungal activity against the microorganism Candida albicans, utilizing two separate concentrations (۵۰ and ۱۰۰) mg/ml. The data indicate that higher concentrations enhance antibacterial and antifungal action, and the Pt-complex exhibits more synergistic effectiveness and demonstrates excellent antibacterial properties against Streptococcus pyogenes.

کلیدواژه ها:

acyclovir ، Antimicrobial ، Antioxidant ، Mannich base ، spectral data