Causes of Perimenopause Bleeding and Association with Thyroid Dysfunction: A Cross-Sectional Study

Background & Objective: Perimenopause period is the transitional period ۲-۸ years before and one year after the last menstrual period. The most common complaint in this period includes abnormal uterine bleeding; the cause may be structural and non-structural, thyroid hormone known to affect reproductive biology. This study was conducted with aim to evaluate the correlation between thyroid disorder and different causes of abnormal uterine bleeding in perimenopause women.Materials & Methods: This cross-sectional study was conducted in Iraq\Babylon province from September ۲۰۲۳ to April ۲۰۲۵. The sample population were ۴۹ women aged ۴۰-۵۱years old who complain from abnormal uterine bleeding. TFT, CBC; transvaginal ultrasound and endometrial biopsy was performed for the patients. Data were analyzed using SPSS software (version ۲۶). P≤ ۰.۰۵ was considered statistically significant.Results: The mean age of participants was ۴۴ years old, with ۵۳.۱% (۲۶ women) between ۴۰ and ۴۵, ۳۱(۶۳.۳%) multiparous, ۳۸(۷۷.۶%) euthyroid, ۱(۲%) hyperthyroid, and ۱۰(۲۰.۴%) subclinical hypothyroid. There was a significant relationship between thyroid function and irregular bleeding (P<۰.۰۵). Among women, ۱۹(۳۸.۸%) had menorrhagia, ۱۶(۳۲.۷%) poly menorrhoea, ۱۰(۲۰.۵%) intermittent bleeding, and ۴(۸.۱%) oligo menorrhoea. AUB was caused by dysfunctional uterine bleeding in ۲۴(۴۹%), endometrial hyperplasia (with or without atypia) in ۹(۱۸.۴%), adenomyosis in ۶(۱۲.۲%), fibroid in ۵(۱۰.۲%), and ovarian cyst in ۱(۲%). Thyroid function did not alter abnormal uterine haemorrhage causes.Conclusion: Most women presented with menorrhagia and poly menorrhea between the age ۴۰-۴۵ years with dysfunctional uterine bleeding being the most common cause, and there was strong association between thyroid dysfunction and abnormal uterine bleeding.

کلیدواژه ها:

Perimenopause ، Bleeding ، Thyroid ، dysfunction