β-Cyclodextrin-Based Metal–Organic Framework as a Novel Functional Bioactive Carrier: A study for Quercetin Delivery

Quercetin is a natural flavonoid with strong antioxidant and therapeutic potential; yet, its practical use is hindered by poor aqueous solubility. To overcome this limitation, this study develops a functional carrier system based on a β-cyclodextrin metal–organic framework (β-CD-MOF) modified with cetyltrimethylammonium bromide (CTAB). In this design, CTAB acts as a surface-active modifier that improves the interaction between quercetin and the framework, while β-cyclodextrin provides hydrophobic cavities capable of accommodating bioactive molecules. Structural and morphological characterizations using FTIR, XRD, SEM, and PSA confirm the successful synthesis and modification of the material. In vitro release studies reveal a biphasic and controlled release profile, accompanied by a notable improvement in quercetin solubility compared to its free form. Overall, these findings demonstrate that CTAB-modified β-CD-MOF effectively encapsulates quercetin and enhances its dissolution behavior, highlighting its potential as a promising carrier system for hydrophobic compounds.

کلیدواژه ها:

Quercetin ، &beta ، -Cyclodextrin-MOF ، CTAB ، Drug delivery system ، Novel functional