Effect of probiotic administration on the severity of morphine dependence in rats

Background and Aim: The rapid advancement of knowledge on the relation between gut microbiota and nervous system disorders resulted in the alteration of pattern in neuroscience and the better understanding of pathophysiology and treatment of psychiatric disorders. However, rare systematic studies are carried out on the relation between Microbiota-Gut-Brain axis and its role in addiction. Addiction may be considered as a form of neural plasticity due to narcotics. Methods: The rats (n=۶۰, weight ۱۸۰-۲۰۰) were divided in ۶ group. The morphine (۷.۵mg/kg) was used as the effective dose. The Prodigest (consisting Lactobacillus acidophilus, Bifidobacterium bifidum Bifidobacterium longum) and Prokid (consisting Lactobacillus acidophilus, Bifidobacterium lactis Lactobacillus rahamnosus Bifidobacterium bifidum) were gavaged for ۸ days. Results: Therefore, it is hypothesized that alteration in gut microbiota can play major role in the process of addiction. Conditioned place preference is one of the routine animal models for studying the rewarding role of narcotics (e.g. morphine). Conclusion: Only the Predigest, but not Prokid significantly resulted in increased staying in the morphine chamber. Considering the increased place preference index induced by morphine, it can be concluded that Prodijest product acts via the same path that the morphine does, so that can potentiate the morphine effect.

کلیدواژه ها:

Conditioned Place Preference ، Morphine ، Probiotic ، Rat