Evaluation of The therapeutic effects of kaempferol on scopolamine-induced amnesia in male Alzheimer's model mice

Background and Aim: Alzheimer's disease is a neurodegenerative disorder that is one of the complications of spatial memory loss. Flavonoid-rich diet is associated with lower rates of dementia and has beneficial effects on memory and learning, and "Kaempferol", a flavonoid, probably has neuroprotective activity and plays a protective and protective role in Alzheimer's disease. Methods: Thirty-five male Wistar rats weighing ۲۰۰-۲۵۰ g were divided into five groups, each containing seven rats: normal control, sham-soluble drug group. The scopolamine group received ۱.۵ mg/kg scopolamine for ۱۵ consecutive intraperitoneal days, the treatment group received ۱۰ mg/kg doses of "Kaempferol" in addition to scopolamine, and the "Kaempferol" group received kaempferol with They received ۱۰ mg/kg dose and all groups were evaluated behaviorally. Results: To determine the effect of kaempferol on the memory and learning of male rats that were obliterated by scopolamine by behavioral testing using a Y-shaped maze. Conclusion Injection of scopolamine significantly reduced spatial memory learning in rats compared to the control group but did not change the motor activity of rats compared to the control group. Cefferol injection increased the spatial memory learning of the rats in comparison with the control group but did not change the motor activity of the rats compared to the control group. Conclusion: Caemferol enhances learning and memory in mice with Alzheimer's disease. Scopolamine has a negative effect on memory and learning and causes forgetfulness.

کلیدواژه ها:

kaempferol ، scopolamine ، Alzheimer's disease ، Flavonoids