Synthesis of ۱-Aryl Pyrroles in the Presence of Nanocellulose/Ti(IV) under Microwave Irradiation

Heterocyclic chemistry is undoubtedly the largest and most diverse discipline of organic chemistry. In a particular way, heterocyclic molecules containing nitrogen have always and forever played a vital role in the pharmaceutical and agrochemical sectors. As a result of their diverse pharmacological effects, including antioxidant, antifungal, antibacterial, anticancer, and antiviral properties, substantial efforts have been made to develop novel processes for the production of functionalized pyrroles. The most common technique for obtaining pyrroles is the Paal-Knorr reaction of a ۱,۴-dicarbonyl molecule with a wide range of primary aromatic amines, which requires a specific reagent or forced reaction conditions. Many techniques for the synthesis of N-aryl pyrroles have been reported with the use of various catalysts. Herein, we wish to report the synthesis of N-aryl pyrroles using various primary aromatic amines and ۲,۵-hexanedione in the presence of nanocellulose/Ti(IV) as a green catalyst under microwave irradiation conditions. Microwave irradiation reduces reaction time and increases product yield. Not only is the utilization of nanocellulose/Ti(IV) catalysts environmentally benign, but it also facilitates the efficient reduction of production costs. The novelty of this work lies in the use of a nanocellulose-supported Ti(IV) catalyst under microwave irradiation, which, to the best of our knowledge, has not been reported previously for the synthesis of N-aryl pyrroles. This methodology provides a sustainable, time-saving, and high-yielding alternative compared to conventional approaches.

کلیدواژه ها:

N-Aryl pyrrols ، Aromatic amines ، ۲ ، ۵-Hexanedione ، Microwave irradiation ، Nanocellulose/Ti(IV)