Regulatory Role of lncRNA MEG۳ in Diabetes Mellitus and Its Complications

Long non-coding RNAs (lncRNAs), defined as transcripts exceeding ۲۰۰ nucleotides in length that do not encode proteins, were once dismissed as transcriptional byproducts with no significant biological function. However, contemporary research has illuminated the crucial functions of the lncRNA maternally expressed ۳ gene (MEG۳), which is involved in key cellular activities, including proliferation, differentiation, and metabolism, as well as in the disease mechanisms of diabetes. This review explored the regulatory capabilities of lncRNA MEG۳ concerning diabetes and its related complications.