The effect of HIRT training combined with beta-alanine supplementation on purine indices and serum carnosine levels in athletes

The aim of the present study was to investigate the effect of eight weeks of HIRT training combined with beta-alanine supplementation on purine and carnosine indices in female athletes.Materials and Methods: In this quasi-experimental study with a pre-test-post-test design, ۴۰ female athletes (mean age ۲۳.۵۷ ± ۱.۸۲ years, mean weight ۵۸.۱۵ ± ۲.۴۰ kg, height ۱.۶۰ ± ۰.۰۲ m, fat mass ۲۳.۳۹ ± ۰.۶۰%, muscle mass ۲۳.۱۵ ± ۰.۸۵ kg) participated and were then randomly divided into ۴ groups: exercise + supplement, exercise + placebo, supplement, and control. High-intensity resistance training was performed three times a week, each session lasting ۶۰ minutes at an intensity of ۸۰ to ۸۵% of one repetition maximum in a circuit with ۶ to ۸ repetitions and ۳۰-۶۰ seconds of rest between each movement and ۱۲۰ seconds of rest between each round of the circuit. The groups receiving the supplement received ۶ grams of beta-alanine in powder form daily. Data were analyzed using one-way analysis of variance and Tukey's post hoc test.Findings: The results showed that after eight weeks of HIRT training with beta-alanine supplementation, hypoxanthine levels significantly decreased (P<۰.۰۰۱), while hypoguanine phosphoribosyl levels significantly increased (P<۰.۰۰۱). Also, serum carnosine levels were significantly increased (P<۰.۰۰۱).Conclusion: Based on the results of this study, it can be concluded that high-intensity resistance training and beta-alanine supplementation improve the purine cycle and carnosine buffering factor in female athletes.

کلیدواژه ها:

HIRT ، beta-alanine supplementation ، purine cycle ، carnosine