Recent Advances in Lophomonas Diagnosis: Traditional and Innovative Techniques for an Emerging Neglected Disease

Background: Lophomonas, a parasitic infection which affects the respiratory system, remains an emerging neglected tropical disease with significant diagnostic challenges. Traditional diagnostic methods, such as microscopy and culture, have proven insufficient for providing accurate and timely detection. Due to their low sensitivity and reliance on specialized equipment, these methods have contributed to delays in diagnosis, particularly in endemic regions. Materials and Methods: This review explores recent advances in Lophomonas diagnosis, focusing on molecular diagnostic techniques like PCR, immunological assays (such as ELISA and lateral flow tests), and emerging technologies like next-generation sequencing (NGS) and artificial intelligence (AI)-driven data analysis. A comprehensive analysis of the latest scientific literature and recent publications on diagnostic innovations for Lophomonas is presented. Results: The results demonstrate significant progress in Lophomonas diagnosis, with molecular and immunological methods showing improved sensitivity and specificity. PCR-based diagnostics offer high accuracy in identifying the parasite, while rapid diagnostic tools like lateral flow tests have proven effective for quick detection, especially in resource-limited settings. Additionally, next-generation sequencing and AI technologies are emerging as cutting-edge techniques, offering potential for automated, high-throughput diagnostic systems. Conclusion: Despite notable advancements in diagnostic methods, challenges such as limited access to diagnostic resources in remote regions and the need for standardized protocols persist. These innovations raise hope for improved detection and treatment of Lophomonas, particularly in endemic areas. Ultimately, new diagnostic methods could contribute to better disease management and control, but further research and development of diagnostic tools are essential for broader implementation and success.

کلیدواژه ها:

Lophomonas ، Neglected disease ، PCR