Therapeutic Potential of Montelukast in Inflammatory Diseases and Oxidative Stress: A Comprehensive Review of Animal Studies

Background: Montelukast, a selective leukotriene receptor antagonist, has been widely used in the treatment of asthma and allergic rhinitis. Recent studies have suggested its potential therapeutic effects in various inflammatory diseases and oxidative stress-related conditions beyond its traditional applications. This review aims to evaluate the therapeutic potential of montelukast in these contexts, with a particular focus on animal studies. Materials and Methods: A comprehensive literature search was conducted using PubMed, and Scopus. Studies published between ۲۰۰۰ and ۲۰۲۳ that investigated the effects of montelukast on inflammatory diseases and oxidative stress in animal models were included. The review focused on the mechanisms of action, dosage, routes of administration, and observed outcomes in various disease models. Results: Animal studies have demonstrated that montelukast exhibits significant anti-inflammatory and antioxidant properties in various disease models. In models of neuroinflammation, montelukast showed neuroprotective effects by reducing pro-inflammatory cytokines and oxidative stress markers. In cardiovascular disease models, the drug attenuated atherosclerosis progression and improved cardiac function by modulating inflammatory pathways and reducing oxidative damage. Additionally, montelukast demonstrated protective effects in models of liver and kidney injury by suppressing inflammatory mediators and enhancing antioxidant defenses. The drug's efficacy was observed across different dosages and administration routes, with oral administration being the most common. Conclusion: The reviewed animal studies provide compelling evidence for the therapeutic potential of montelukast in a wide range of inflammatory diseases and oxidative stress-related conditions. Its ability to modulate both inflammatory pathways and oxidative stress makes it a promising candidate for repurposing in various pathological conditions. However, further research, including clinical trials, is necessary to fully elucidate its efficacy and safety in human patients with these conditions.

کلیدواژه ها:

Montelukast ، inflammation ، oxidative stress ، animal studies ، leukotriene receptor antagonist