Multifunctional Biological Wound Dressing Containing Growth Factors and Antimicrobial Nanostructures for Accelerated Wound Healing and Infection Prevention

This study presents an advanced biological wound dressing composed of a multilayer composite structure. The core consists of a porous hydrogel based on natural biopolymers (e.g., Type I collagen, alginate, modified chitosan), intelligently loaded and enhanced with: Controlled-release growth factors (e.g., PDGF, VEGF, EGF) that release optimally to stimulate cell proliferation, angiogenesis, and extracellular matrix regeneration and Targeted antimicrobial nanostructures: Silver or copper nanoparticles with biocompatible coatings and optimized size for maximum efficacy and minimal cytotoxicity, effective against broad-spectrum bacteria (including MRSA and Pseudomonas). Anti-inflammatory/anti-scarring agents: Microencapsulated curcumin or targeted siRNA to reduce chronic inflammation and regulate collagen expression for hypertrophic scar prevention. Electroconductive nanofibers for mild electrical stimulation to enhance cell migration and proliferation. The outer layer is a thin, flexible semi-permeable polymer film allowing gas exchange (O₂, moisture), acting as a physical barrier against bacteria/contaminants, and preventing wound adhesion. The entire structure selectively adheres to moist wound tissue while enabling painless removal without damaging regenerating tissue. This system shows potential as a gold standard for diabetic and burn wound management.

کلیدواژه ها:

biological wound dressing ، porous hydrogel based on natural biopolymers