Application of nanotechnology-based transdermal patches in targeted drug delivery for cancer treatment

Cancer treatment, especially through systemic chemotherapy, has always faced challenges such as widespread side effects, reduced quality of life of patients, and the need for repeated high doses. Therefore, the development of new drug delivery methods with the aim of increasing effectiveness and reducing complications is an undeniable necessity.The main objective of this study is to investigate the feasibility and scientific analysis of the use of nanocarrier transdermal patches as a non-invasive method for local treatment of breast cancer, focusing on increasing the effectiveness of the drug in the target tissue and reducing the systemic complications of chemotherapy. This study was conducted using a library method and a systematic review of previous research in the field of transdermal drug delivery, nanotechnology, and cancer treatment. Also, the laboratory method of making the patch by solvent casting technique using PVA and HPMC polymers and adding plasticizer (glycerol) and drug (such as doxorubicin) is described. In the meantime, transdermal drug delivery technology, as a non-invasive and novel approach, has attracted the attention of researchers. Transdermal patches with the ability to deliver controlled drugs, reduce the dose, and target more precisely, can play an effective role in the local treatment of some cancers, especially breast and skin cancer. This article aims to scientifically analyze and assess the feasibility of using transdermal patches in cancer treatment, and to examine the technical capabilities, implementation challenges, and opportunities for localization of this technology in Iran. The findings of this study indicate that if research and industrial infrastructures are provided, transdermal patches can be used as an effective, safe, and cost-effective option in cancer treatment in the country. Finally, directions for future research and clinical study design are suggested. The findings show that transdermal patches, especially the advanced generations containing nanocarriers (liposomes, nanoparticles) and penetration enhancement technologies (such as microneedles), have Reduced systemic side effects by bypassing hepatic and first-pass metabolism.

کلیدواژه ها:

transdermal drug delivery ، anticancer patch ، nanotechnology ، controlled drug release ، localization ، microneedle