Targeted Immune–Neural Reprogramming (TIR-MS): A Precision Framework for Restoring Remyelination in Chronic Multiple Sclerosis Lesions

Multiple sclerosis (MS) exemplifies a profound failure of endogenous repair mechanisms, driven by chronic inflammation, demyelination, and neurodegeneration. While current therapies effectively manage acute flares, they fail to address persistent barriers to remyelination in chronic lesions.We propose Targeted Immune–Neural Reprogramming (TIR-MS), a tripartite, adaptive framework:۱. High-resolution multimodal biomarkers defining lesion-specific inhibitory milieus via a Regenerative Readiness Index (RRI).۲. Selective immune reprogramming to neutralize pathogenic cellular states without systemic compromise.۳. Context-sensitive cues to unblock oligodendrocyte progenitor cell (OPC) differentiation.TIR-MS operates as a dynamic computational loop—measure → recalibrate immunity → promote repair → reassess—transforming chronic MS pathology from stalled inhibition to regenerative homeostasis.

کلیدواژه ها:

Immune–Neural ، Remyelination ، Chronic Multiple