The Effects of Verapamil and Adenosine in the Treatment of Paroxysmal Supraventricular Tachycardia

Introduction: There are several drug medicines in the treatment of Paroxysmal Supra-ventricular Tachycardia (PST) after the inefficacious vagal stimulus. This study aimed to compare two treatments: Verapamil versus adenosine triphosphate (ATP) for treating Paroxysmal Supraventricular Tachycardia. Methods: Sixty-six patients with PST were treated with either Verapamil (۵ to ۱۰ mg) or ATP (۵ to ۲۰ mg). The basal features of each group and the efficacy and safety of the two drugs were compared. Verapamil failures were treated with ATP and vice versa. Results: The mean heart rate after treatment in all patients was ۷۹.۴۶ ± ۱۰.۶۷, compared to baseline in both groups, showed a decrease significantly (P <۰.۰۰۱)) The mean heart rate after treatment in adenosine was ۸۷.۲۷ + ۸.۳۹ and ۷۱.۶۶ ± ۵.۹۵ in the verapamil group. Between groups in heart rate, significant differences were observed after treat-ment of the screw (P<۰.۰۰۱). Of the total, ۱۲ (۱۸.۲%) had a recurrence of adenosine in ۶ patients (۹.۱%), and Verapamil in ۶ patients (۹.۱%) had a recurrence. The Average time converted to sinus rhythm in all patients was ۳۲.۰۴+۱۲.۷۹ minutes. Average time con-verted to sinus rhythm verapamil group and ۳۶.۰۶ ± ۱۲.۹۷ minutes in the adenosine group and ۲۸.۰۳+ ۱۱.۴۵ minutes (P = ۰.۰۱).Conclusions: The more effective the drug verapamil over adenosine is in treating PSVT, the longer it proves its effectiveness. Except for headache, side effects were higher in patients treated with adenosine. In other cases, there was no difference between the two drugs.

کلیدواژه ها:

Adenosine ، Verapamil ، PSVT ، Side Effects