Polyphenol Intake and the Risk of Pancreatic Cancer: A Systematic Review and Meta-analysis of Observational Studies

Background: Considering the antioxidant effects of polyphenols, it remains unclear whether dietary polyphenols can affect the risk of pancreatic cancer. This study assessed the association between polyphenol intake and the risk of pancreatic cancer. Methods: Articles published until April ۲۰۲۳ in PubMed, Scopus, and the Web of Science (ISI) were searched. Observational studies on the association between dietary polyphenol intake and the odds of pancreatic cancer were also included. Odds ratios (ORs) with ۹۵% confidence intervals (CIs) were used as effect sizes. Furthermore, standard methods were used to evaluate the heterogeneity, sensitivity, and publication bias. The Newcastle-Ottawa Scale (NOS) was used for quality assessment. Results: Eight studies were included. Although this systematic review and meta-analysis revealed no relationship between the intake of total flavonoids, flavan-۳-ols, flavones, flavonols, flavanones, anthocyanidins, and pancreatic cancer odds; in qualitative analysis, a positive relationship was observed between genistein and the aflavin intake and pancreatic cancer risk. Conclusions: No relationship was observed between polyphenol intake and pancreatic cancer odds. Polyphenols have poor bioavailability and bioaccessibility, which may have affected their results. Therefore, more high-quality studies with precise designs are required to determine whether a relationship exists.

کلیدواژه ها:

Polyphenol ، Flavonoid ، Pancreatic cancer ، Observational studies