Protective Effects of Nano-Propolis Liposomes on Iischemia-Reperfusion Injury: A Rat Model of Testicular Torsion and Detorsion

A rat testis model was used to assess the effects of nano-propolis liposomes on ischemia-reperfusion injury. Twenty-four healthy male Wistar rats were included and randomised into six investigational groups (n = ۶): Group SHAM: only laparotomy was implemented. Group ISCHEMIA: only a ۳-hour ischemia was induced. Group IS/REP: A ۳-hour ischemia followed by ۳ hours reperfusion for the left testis and one week reperfusion for the right testis was performed with ۱ ml normal saline that was gavaged ۱ hour before the onset of ischemia. Group IS/REP/NPL: As in group IS/REP, but with ۱ ml nano-propolis liposomes gavaged ۱ hour before the onset of ischemia. Evaluations were based on biochemical analyses and sperm parameters. Propolis enhanced antioxidant activity and quality of sperm parameters (p < ۰.۰۵). Nano-propolis liposomes could help minimize ischemia-reperfusion injury in testicular tissue exposed to ischemia.

کلیدواژه ها:

Nano-propolis liposomes ، ischemia-reperfusion ، Testis