Biological Therapies in the Treatment of Knee Osteoarthritis: A Narrative Review

Objective: This study evaluates the efficacy and safety of biological therapies in treating knee osteoarthritis (OA), focusing on platelet-rich plasma (PRP), hyaluronic acid (HA), and stem cell therapies. Methods: A comprehensive review of studies from the past decade was conducted, utilizing databases such as PubMed, CENTRAL, Web of Science, and Embase. Keywords included "knee osteoarthritis," "PRP," "hyaluronic acid," and "stem cell therapies." A total of ۶۷ relevant studies, including reviews, original research, and meta-analyses, were analyzed. Results: Biological therapies offer significant advancements in OA management. PRP demonstrates anti-inflammatory properties and appears to enhance cartilage repair, particularly effective in early to intermediate stages. HA improves joint lubrication and mobility, suitable for mild to moderate OA. Stem cell therapies show promising results in cartilage regeneration and inflammatory modulation, particularly in advanced cases. However, challenges such as standardization, cost, and accessibility limit widespread adoption. Discussion: PRP, HA, and stem cell therapies provide innovative approaches to knee OA treatment, addressing pain, inflammation, and cartilage regeneration. Further research is essential to optimize protocols and improve accessibility, ensuring personalized and effective treatments for diverse patient populations.

کلیدواژه ها:

Knee osteoarthritis ، Biological therapies ، Platelet-rich plasma ، Hyaluronic acid ، Stem cell therapy ، Cartilage regeneration ، Joint function improvement ، Inflammation reduction ، Innovative treatments ، Personalized medicine ​​​​​​​