The effects of High-intensity Interval and Moderate-intensity Continuous Trainings on autophagy, cardiac remodeling and heart function in aged male rats

Introduction: Aging is a physiological process affecting the heart function. Training is known as a factor accelerating the heart output specially in aged individuals. In the present experimental study, The authors aimed to evaluate how High-intensity interval training (HIIT) and Moderate-intensity continuous training (MICT) affect autophagy, cardiac remodeling and cardiac functionMethods: Twenty-four male Wistar rats, approximately ۲۰ months old, were divided into three groups of Control, HIIT and MICT. The high-intensity interval and moderate-intensity continuous trainings lasted for ۸ weeks. Aerobic power and training capacity were also assessed. ۲ dimensional echocardiography was also applied for assessment of cardiac indices. At the end of the experiment, tissue sampling of cardiac tissue was applied and gene expression was assessed using qRT-PCR technique. Data were analyzed using SPSS (v.۱۹) softwareResults: After HIIT and MICT trainings, no significant changes were detected regarding the animal weight. Also, mTORC۱, Atg۱۶, and Atg۷ gene expression and EF and FS were accelerated in HIIT and MICT groups than control animals. Besides, COLIII gene expression, LVEDD, and LVESD showed a significant increase (p<۰.۰۵) in HIIT and MICT animals than controlConclusion: Training can potentially improve the cardiac output in elderly. Besides, the HIIT seems effective than MICT

کلیدواژه ها:

Aging ، cardiac output ، echocardiography ، High-intensity interval training ، Moderate-intensity continuous training ، mTORC۱ ، Atg۱۶ ، Atg۷ ، COLIII ، LVEDD ، LVESD ، EF ، FS