Comparison of the Severity of Neonatal Abstinence Syndrome Manifestations in Newborns Exposed the Natural and Synthetic Opioids

Background: The study aimed to investigate the severity of Neonatal Abstinence Syndrome (NAS) complications in newborns (NBs)  in the eastern region of Iran. Methods: The retrospective study was conducted among mothers and singleton live births between March ۲۰۲۲ and March ۲۰۲۳. Results: Twenty-nine mothers (۵۳.۷%) used natural opioids (NO) and ۲۵ (۴۶.۳%) synthetic opioids (SO). The highest number with the ۲۰-۳۰ age range. Of the NBs from the NO, ۳۱.۰۳% were before ۳۷ weeks. In contrast, in the SO, ۸۸% were before ۳۷ weeks (p < ۰.۰۵). In the NO, ۸۹.۶۵% weighed < ۲.۵ kg. In contrast, ۱۰۰% of those in the SO weighed > ۲.۵ kg. In SO exhibited crying for >۱۰ minutes at a high. Additionally, SO had a high frequency of sleep (P<۰.۰۵). The SO showed a high frequency of metabolic disorders (P<۰.۰۵). The frequency of sneezing was high in the SO (P<۰.۰۵). Nasal flaring was high in the SO (P<۰.۰۵). Respiratory rate index, defined as more than ۶۰ breaths per minute and retractions> ۶۰ breaths per minute, were high in the NO and SOs, respectively (P<۰.۰۵). Excessive sucking and poor nutrition were high in the NO, and SO, respectively (P<۰.۰۵). The regurgitation index (grade ۳), and loose stools and watery stools were high in the SO (P < ۰.۰۵). Conclusion: The study highlighted the impact of the NB's gender and age at birth on the severity of the NAS symptoms, esprcially in SO group.

کلیدواژه ها:

Gastrointestinal Disorders ، Neonatal Abstinence Syndrome ، Nervous System Diseases ، Opioids ، pregnancy ، Respiration Disorders