The Role of Adipose Tissue-Derived Stem Cells together with Vitamin C on Survival of Rats with Acute Radiation Syndrome

Background: Following any injury in radiation accidents, such as Acute Radiation Syndrome (ARS), medical interventions are recommended based on radiation dose and physiological response. Clinical management encompasses blood transfusion, hematopoietic cytokines, and stem-cell transplantation.Objective: This study aimed to determine the effect of adipose tissue-derived stem cells (AdSCs) together with vitamin C on the survival of rats with ARS.Material and Methods: In this experimental study, ۴۵ rats were randomly divided into ۳ equal groups of animals administered with a single dose of oral ۴۰۰ mg/kg vitamin C; those injected intravenously with ۱.۵×۱۰۵ AdSCs; and rats transplanted intravenously with ۱.۵×۱۰۵ AdSCs together with a single oral dose of ۴۰۰ mg/kg vitamin C. All rats were already irradiated with ۱۰ Gy (dose rate ۰.۲۸۶ Gy/ min) ۶۰CO, for ۳۵ minutes with a field size of ۳۵ cm × ۳۵ cm for all body areas.Results: A significant increase in survival rate was visible one month after γ irradiation in ۷۳.۳% of animals received AdSCs+vitamin C, ۶۰% of rats injected with just AdSCs, and ۱۳.۳% of the group received just vitamin C. Conclusion: Our findings revealed significant efficacy of a combined approach involving AdSC transplantation and vitamin C to enhance the survival rate following lethal irradiation. This combination could offer a potential avenue for addressing the alleviation of tissue damage caused by chemotherapy and toxic drugs. We recommend the administration of AdSCs together with vitamin C as an effective and prompt treatment option for irradiation injuries.

کلیدواژه ها:

Acute Radiation Syndrome ، Mesenchymal Stem Cells ، Adipose tissue ، Survival ، Rat