Numerical Study of the Role of Nanoparticles in Breast Tumor Treatment in ۳D

In this paper, we conducted a numerical study to investigate the role of magnetic nanoparticles (MNPs) in the treatment of cancerous tissues in three dimensional. First, we considered the governing equations associated with this method. Next, we utilized the finite element method (FEM) and Comsol Multiphysics software package to calculate parameters such as temperature distribution, generated heat, and the fraction of damage in tumor and normal tissues over a ۴۰-minute period. The applied frequencies and current in the coil were ۱۵۰ and ۳۰۰ kHz and ۵۵۰ A, respectively. Our calculations revealed that the maximum temperatures of the tumor at frequencies of ۱۵۰ and ۳۰۰ kHz were ۴۵.۴ and ۴۷ degrees, respectively. These temperatures are sufficient to destroy cancer cells. Furthermore, the comparison of results at ۱۵۰ and ۳۰۰ kHz frequencies demonstrated that parameters such as temperature, heat, and degradation rate increase with the increase of frequency. Additionally, we found that the tumor damage at the end of the process for frequencies of ۱۵۰ and ۳۰۰ kHz was ۱۰۰% in the center of the tumor, but reduced to ۶۳% and ۷۵% at the border, respectively.

کلیدواژه ها:

Magnetic hyperthermia ، magnetic nanoparticles ، breast Cancer ، Simulation ، COMSOL Multiphysics