Comparison of Systemic Inflammatory Response Markers Derived from Complete Blood Count between Women with Preeclampsia and Healthy Pregnant Women

Background: Preeclampsia is a significant pregnancy complication with an underlying inflammatory basis, typically occurring after the ۲۰th week of gestation and associated with increased maternal and fetal risks. Identifying simple and effective markers for its prediction and monitoring can play an important role in early diagnosis and effective management of the condition. Objectives: This study aimed to compare systemic inflammatory response markers derived from complete blood count between women with preeclampsia and normotensive pregnant women. Methods: In this case-control study, ۳۲۴ pregnant women, including ۱۶۲ with preeclampsia and ۱۶۲ healthy pregnant women, were evaluated. The CBC indices were calculated from the first blood sample obtained at hospital admission and compared between the two groups and between the subgroups of non-severe and severe preeclampsia. Statistical analyses were applied to examine correlations by using SPSS version ۲۰. Results: This study demonstrated statistically significant differences in NLR, PLR, and SII indices between women with preeclampsia and healthy pregnant women, whereas the MLR index did not differ significantly. In the comparison between non-severe and severe preeclampsia subgroups, only NLR and MLR showed statistically significant differences. Conclusion: The findings of this study suggest that specific inflammatory indices derived from complete blood count may play an important role in the diagnosis and assessment of preeclampsia severity. These indices are simple, accessible, and cost-effective, and can serve as complementary tools alongside standard clinical and laboratory criteria to support early diagnosis and optimal patient management.

کلیدواژه ها:

Preeclampsia ، Neutrophil-to-Lymphocyte Ratio (NLR) ، Platelet-to-Lymphocyte Ratio (PLR) ، Monocyte-to-Lymphocyte Ratio (MLR) ، Systemic Immune-Inflammation Index (SII)