Outcomes of Temple Filler Injections in Facial Rejuvenation: A Systematic Review and Meta-analysis

Temple volumization has become an integral component of facial rejuvenation, aiming to restore youthful contours and address age-related soft tissue loss. Despite the increasing use of dermal fillers in the temporal region, variability exists regarding filler type, injection depth, technique, and clinical outcomes. This systematic review and meta-analysis aimed to evaluate the efficacy, safety, and patient satisfaction associated with temple filler injections. A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, and Cochrane Library databases from January ۲۰۰۰ to December ۲۰۲۵. Studies reporting on outcomes of hyaluronic acid (HA), poly-L-lactic acid (PLLA), and calcium hydroxylapatite (CaHA) in temple rejuvenation were included. Data extraction focused on injection technique, depth, volume, longevity of effect, adverse events, and patient-reported satisfaction. A total of ۶۶ studies encompassing ۳,۲۱۴ patients met inclusion criteria. Meta-analytic pooling demonstrated significant improvement in temporal volume restoration with HA, PLLA, and CaHA, with standardized mean differences (SMD) of ۱.۱۲ (۹۵% CI: ۰.۸۵–۱.۳۹), ۱.۰۵ (۹۵% CI: ۰.۷۷–۱.۳۲), and ۰.۹۸ (۹۵% CI: ۰.۷۰–۱.۲۶), respectively. Complication rates were low, predominantly mild bruising and transient edema, with no serious adverse events reported. Patient satisfaction scores were consistently high, with pooled satisfaction rates exceeding ۹۰% across all filler types. Comparative analysis suggested slightly longer-lasting results with PLLA and CaHA compared to HA. The findings underscore that temple filler injections are effective, safe, and yield high patient satisfaction when performed with proper technique and depth awareness. Limitations include heterogeneity in study designs, follow-up duration, and reporting standards. Future research should focus on standardized injection protocols, long-term outcomes, and comparative studies between filler types. Overall, this meta-analysis provides evidence-based guidance for clinicians to optimize temple rejuvenation strategies and enhance patient-centered outcomes.

کلیدواژه ها:

Temple fillers ، Facial rejuvenation ، Hyaluronic acid ، poly-L-lactic acid ، Calcium Hydroxylapatite